It reportedly occurred at 11:20 p.m. in the 15,500 block of the Bristol Highway. A 2011 Chevrolet pickup was traveling west when it ran off the left side of the highway and struck a tree.
Police say the adult male driver was flown to Bristol Regional Medical Center for treatment of life-threatening injuries. An adult female passenger died at the scene.
She has not been publicly identified, as the VSP are still in the process of notifying her next-of-kin.