Josh Sheridan caught a 7-yard touchdown pass from Josh Jones and scored on a 12-yard run to give the Braves (4-7) a 14-0 halftime lead.
Terrence Lambert scored the lone touchdown for the Cavaliers (2-9) on 6-yard run. The score capped a five-play, 40-yard drive set up by CJ Hughes’ fumble recovery.
Hunter Braswell booted field goals of 25 and 40 yards in the fourth quarter to set the final margin.
Wise freshman quarterback Lendon Redwine finished 17-of-29 passing for 90 yards. It was a rough day for the former Dobyns-Bennett standout, who was sacked four times and intercepted four times.
Lambert led the Cavaliers on the ground with 11 carries for 66 yards.
Sheridan carried 14 times for 107 yards and DeAngelo Blair-Young had 13 carries for 73 yards for the Braves.
Marcus Tarrer led UVa.-Wise with a dozen tackles, and former Happy Valley standout Austin Hicks made eight stops.
EMORY & HENRY 59, FERRUM 36
EMORY — Emory & Henry freshman running back Grayson Overstreet ran for an Old Dominion Athletic Conference-record 322 yards and two touchdowns in the win over Ferrum (4-6, 3-5) at Fred Selfe Stadium.
The Wasps eclipsed the 50-point mark for the third time this season and scored their highest total since a 70-27 win over Guilford in the final game of the 2018 season.
Emory & Henry (7-3, 6-2) completed its first winning season since 2016. Wasps quarterback Hunter Taylor connected on 15 of 29 passes for 225 yards and four touchdowns.
Gunner Griffith, a former Sullivan East star, hauled in six catches for 136 yards and two touchdowns. Senior Matt Seals, who played at Cherokee, converted on a 44-yard field goal.
Derrick Yates, an Abingdon product, concluded his Wasps career with two touchdowns on four catches for 47 yards.
Former Dobyns-Bennett star Ivan Phillips had nine tackles to lead the E&H defense.
CARSON-NEWMAN 49, TUSCULUM 13
JEFFERSON CITY — The Carson-Newman defense piled up 10 sacks to tie for the most in team history, and the Eagles throttled South Atlantic Conference rival Tusculum at Burke-Tarr Stadium.
The Eagles (8-2, 6-2) added 15 tackles for loss and held the Pioneers (5-6, 4-4) to minus-35 net yards on the ground.
Carson-Newman’s offense won the yardage battle 451-149, rushing for 348 yards and six touchdowns — three of them by quarterback Tyler Thackerson. Thackerson also threw for a score and finished with 115 yards through the air.
Antonio Wimbush finished with a game-best 159 all-purpose yards and scored on a 18-yard run for the Eagles.
Carson-Newman, back in the postseason for the first time since 2015, heads to Maryland to take on Bowie State in the opening round. The teams have never met.
The Eagles are in the NCAA Division II playoffs for the 16th time but first under third-year head coach Mike Turner.
Carson-Newman is one of three SAC teams to make the field. Wingate hosts West Florida and Lenoir-Rhyne takes on Miles.