He told a news conference Tuesday: "We've slipped. It's my fault. I'm the head coach."
Spurrier was in the middle of his 11th season. The Gamecocks were 2-4 overall and 0-4 in the Southeastern Conference for the first time in Spurrier's career.
He had never had a losing season in 25 previous seasons coach at Duke (1987-89), Florida (1990-2001) or South Carolina, where he has been since 2005.