Mark Zagunis and Andrew Rash each drove in three runs to help the Hokies (39-21), who already have one loss in the double-elimination tournament. Coastal Carolina (37-23) was eliminated.
Burke (11-3) pitched his second complete game of the season, allowing a home run to Jacob May in the ninth inning. He struck out two and walked two in winning his sixth straight decision.
Rash and Chad Pinder each hit solo homers for Virginia Tech. The Hokies broke open the game with a five-run ninth, highlighted by Zagunis' two-run single and Rash's two-run double.
Coastal Carolina's Ben Smith went 6 1-3 innings and gave up two runs.