Pinder and Tyler Horan each had three hits for the sixth-seeded Hokies (36-19), who had a six-run second inning against the third-seeded Cavaliers (45-10). Pinder hit a two-run shot in the second, then blew the game open with a blast over the left-field wall in the sixth.
Chad Morgan and Brendon Hayden added consecutive RBI doubles in the second for Virginia Tech. Joe Mantiply (6-0) earned the win by allowing one run in seven innings.
Virginia starter Brandon Waddell (5-2) allowed six runs and 10 hits in four innings.
The Cavaliers will face seventh-seeded Georgia Tech on Thursday in Pool B. The Hokies will play No. 2 seed Florida State.