The girls begin play Friday at satellite sites with all games starting at 7 p.m. Science Hill (29-3) will host Sevier County (15-17) with Daniel Boone (17-12) traveling to take on Morristown West (20-9).
Volunteer (18-15) will be at Cocke County (20-9) with Tennessee High (24-5) hosting Morristown East (11-18).
Friday's winners advance to the Region 1 semifinals at Boone on Monday.
On the boys side, play begins on Saturday with South Doyle (9-21) traveling to Science Hill (34-2) for a 6 p.m. contest.
The remainder of the boys games will start at 7 p.m. Jefferson County (22-9) will host Daniel Boone (21-9) with Sullivan South (14-16) going to Sevier County (26-4).
Dobyns-Bennett (20-8) will host Cocke County (17-12) in the Buck Van Huss Dome.
Saturday's winners play in the boys regional semifinals on Tuesday, also at Daniel Boone.
The girls and boys championship games will also be played at Boone. The girls meet on Wednesday with the boys playing their final on Thursday.
Admission for all games is $6.