McCarthy has not played since injuring the ankle in the season opener against New England. He practiced Wednesday and was limited Friday, so coach Mike Munchak said they will have to see how much they can use the defensive captain against the Vikings (3-1).
"We'll have to see how the game goes and what kind of game it is," Munchak said. "We're going there to win, and we need him on the field, So if he can help us win, we're doing that. We'll have to see how he is on Sunday. If we have to limit him, we'll decide what package to keep him in."
Britt will test his ankle Saturday and before the game Sunday to determine if he can play. He has played only one game this season in the Titans' overtime win Sept. 23 against Detroit.
"Whoever is healthy to play and we feel can help us will go in there and play. If we feel they're both good and can contribute to Sunday, then we'll have them on the field. If we feel they can't help us, then there's no reason them to play, and we'll wait till Thursday," said Munchak, whose team faces a quick turnaround hosting Pittsburgh on Thursday.
Tight end Jared Cook said his injured left shoulder is feeling better, and he is probable for Sunday.
"I feel a lot better than last week," said Cook who sprained his AC joint against Detroit. "It just comes with the territory. It's gonna take some time to fully heal, but it feels a heck of a lot better."
Defensive end Scott Solomon (hamstring) and linebacker Patrick Bailey (hand) both practiced Friday and are questionable as is tackle Mike Otto (hand/knee).
Jake Locker was ruled out earlier in the week due to a dislocated left shoulder with Matt Hasselbeck starting for the Titans (1-3).