Verlander (4-1) allowed two runs and struck out seven before leaving the game when Kevin Youkilis hit a solo home run in the eighth. The reigning AL Rookie of the Year, Verlander has allowed four earned runs in four road starts this season.
The Tigers have won 12 of 15 games despite losing their previous two.
Wakefield (4-4) was leading the AL in opponents' batting average, second in the league in ERA and hadn't allow a run in his two previous starts. But Inge hit a solo homer in the third to snap his shutout streak at 16 innings. After Curtis Granderson and Gary Sheffield singled, Ordonez homered over the Green Monster to make it 4-1.
CLEVELAND - Paul Byrd (3-1) won for the first time in three starts in May and the Indians had two six-run innings in accumulating season highs in hits and runs.
Jhonny Peralta homered and had four RBIs, Grady Sizemore had four hits, including a two-run homer, and Josh Barfield had three hits and three RBIs for the Indians.
Peralta's three-run homer keyed a six-run first off Ramon Ortiz (3-4). Cleveland had 17 hits.
Justin Morneau, in his second game since having his nose broken Saturday, hit two solo homers for Minnesota. It was his sixth career two-homer game.
Byrd (3-1) allowed five runs and seven hits over seven innings. The right-hander struck out seven without a walk.
TORONTO - Jesse Litsch pitched into the ninth inning in his major league debut and Troy Glaus singled in the go-ahead run in the sixth.
Litsch walked Miguel Tejada with two outs in the ninth and Jeremy Accardo relieved. Accardo allowed a single to Ramon Hernandez before retiring Aubrey Huff on a groundout to second to earn his third save. Litsch, who allowed just four singles, walked three and struck out one, became the first Blue Jay to win his debut as a starter since left-hander Gustavo Chacin beat the Yankees on Sept. 20, 2004, at Yankee Stadium.
Jeremy Accardo earned his third save.
Daniel Cabrera (3-4) threw a complete-game three-hitter to keep the Orioles in it.
KISSIMMEE, Fla. - Brendan Harris' bases-loaded single in the 10th, his fourth hit of the game, drove in the winning run off Scott Feldman (1-2).
Brian Stokes (2-5) pitched the 10th for the Devil Rays, who were playing at Disney's Wide World of Sports complex in hopes of raising the franchise's profile in the Orlando area and bolstering television ratings across Central Florida.
NEW YORK - Aramis Ramirez hit a grand slam and Carlos Zambrano pitched eight sharp innings, sending Chicago to a rout of New York.
Cliff Floyd had three hits and an RBI in his first start at Shea Stadium since spending the previous four seasons with the Mets, and Chicago handed John Maine (5-1) his first loss of the year.
Daryle Ward hit a two-run double in the first, Michael Barrett doubled twice and drove in two runs, and left fielder Alfonso Soriano threw out a runner at the plate in the second to keep the score 3-0. Ramirez's seventh career slam, off Scott Schoeneweis, broke open the game in a six-run sixth. The Cubs finished with 15 hits.
Zambrano (4-3) allowed six hits, walked three and struck out three. He has won three of his past four starts.
Shawn Green hit his fifth home run for the Mets, who had won five of six and nine of 12. Carlos Delgado left in the seventh, one inning after he was hit on the left hand by Zambrano's pitch. X-rays were negative and he is day to day with a bruised pinky.
PHILADELPHIA - Carlos Ruiz hit a solo homer with two outs in the ninth to lift the Phillies.
Brett Myers allowed Johnny Estrada's tying solo homer in the ninth for his first blown save, but Ruiz connected off Derrick Turnbow (1-2) for his first career game-winning homer.
Estrada led off the ninth with his fifth homer. Myers (1-2) had converted his first four save opportunities since replacing injured closer Tom Gordon, and hadn't allowed a run since his first relief appearance. Myers, who was the opening-day starter, has a 1.08 ERA in 16 2-3 innings as a reliever.
Turnbow, the losing pitcher Monday night, retired the first two batters in the ninth. But Ruiz drove a 2-1 pitch into the left-center field seats for his third homer.
The Phillies have won five of six.
WASHINGTON - Edgar Renteria hit two home runs, Tim Hudson allowed three hits over seven innings, and the Braves ended the Nationals' four-game winning streak.
Renteria went 3-for-5, homering in the first and seventh innings as the Braves snapped a two-game losing streak. Atlanta has won six of its past eight.
Hudson (5-1), inducing ground ball after ground ball, had a perfect game through 4 2-3 innings and lowered his ERA to 1.77. Hudson walked one and struck out four before leaving for a pinch hitter in the eighth.
The Braves punished Nationals starter Jerome Williams (0-5), who failed again to get his first win since 2005. Renteria's home runs were his fifth and sixth of the season.
PITTSBURGH - Dan Uggla drove in four runs while hitting two of Florida's four homers, helping Sergio Mitre win for the first time in a year.
Hanley Ramirez also homered while reaching base five times for Florida, which snapped a four-game losing streak. Jeremy Hermida hit a solo shot as the Marlins won for only the fifth time in their last 18 games in Pittsburgh.
Mitre (1-2) gave up three runs - two earned - and eight hits in 7 2-3 innings, ending a six-game losing streak that spanned 19 appearances since April 4, 2006.
Florida had a four-run sixth against Paul Maholm (2-5) highlighted by Uggla's two-run homer.
DENVER - Randy Johnson allowed one hit over six innings and outdueled Jason Hirsh.
For the second straight start, Johnson (1-2) looked like the Big Unit who won five Cy Young Awards. Johnson, who underwent back surgery last October, struck out nine and walked none in winning for the first time since his return to Arizona after two frustrating seasons with the New York Yankees.
Johnson didn't come out for the seventh after 79 pitches, giving way to right-hander Tony Pena. Pena gave up one hit in two scoreless innings and Jose Valverde finished the three-hitter with his 13th save in 15 chances.
Jason Hirsh (2-4) allowed three earned runs and seven hits in eight innings, walking none and striking out four.
Conor Jackson was the first to solve Hirsh's changeup with his first home run since Oct. 1. Eric Byrnes made it 3-0 when he led off the seventh by stroking a fastball over the wall in left-center for his sixth home run.