A-Rod tied the major league record for home runs in April, hitting his 13th and 14th of the season in a 10-8 loss to the Tampa Bay Devil Rays on Monday night.
Rocco Baldelli and B.J. Upton offset the Yankees star by combining to drive in seven runs for Tampa Bay.
Baldelli hit a three-run homer off Kei Igawa (1-1) in the second inning. Upton lined a solo shot off the left-field foul pole in the fourth for a 5-3 lead, then added a three-run double off reliever Luis Vizcaino to finish with a career- high four RBIs.
The Yankees, swept during a weekend series in Boston, dropped their fourth straight despite getting homers in the second and ninth innings from A-Rod. Rodriguez's average rose to .400 after going 4-for-5 with three RBIs and four runs scored.
The second-inning solo shot off Casey Fossum (2-1) was the 477th of A-Rod's career and extended his hitting streak to 18 games to start this season and 23 in a row dating to last September. The two-run shot off Al Reyes in the ninth gave him 34 RBIs and tied the mark for homers in April set by Albert Pujols in 2006.
Igawa allowed seven runs and eight hits in 4 1-3 innings. New York pitchers have given up six runs or more in five straight games and nine of 18 this season.
KANSAS CITY, Mo. - In his first start since last week's no-hitter against Texas, Mark Buehrle (2-0) allowed two runs and five hits in seven innings.
Paul Konerko, who had not homered since opening day, hit a pair of two-run homers and drove in five runs for the White Sox.
Bobby Jenks worked the ninth for his seventh save, retiring David DeJesus on a game-ending, double-play grounder with two on. Jimmy Gobble (0-1) was the loser.
BOSTON - Frank Thomas hit his 490th homer, a go-ahead, two-run drive off Tim Wakefield (2-20) in the sixth.
Aaron Hill had four hits, including a two-run homer in the ninth, as Toronto ended a five- game losing streak and stopped Boston's five-game winning streak. Hill has four homers in 19 games after getting six in 155 last year.
Tomo Ohka (1-2) allowed three runs - two earned - and six hits in five-plus innings for his first win in eight starts since Aug. 24 at Colorado. Jason Frasor, filling in for injured closer B.J. Ryan, got his second save.
A day after tying a major league record with four straight homers against the Yankees, Boston didn't hit any.
BALTIMORE - Nick Swisher homered twice, including a drive that sparked a five-run fourth against Erik Bedard (3-2), and Oakland ended Baltimore's four- game winning streak.
Swisher hit a two-run homer in the fourth and added a solo shot against Danys Baez in the ninth.
Dan Haren (2-2) allowed one run and five hits in seven innings to lower his ERA to an AL-best 1.41. Huston Street allowed an RBI single to Brian Roberts in the ninth and before getting Miguel Tejada to ground out with the bases loaded for his fifth save.
ARLINGTON, Texas - Ichiro Suzuki went 3-for-5 with a three- run triple as Seattle stopped a six-game losing streak.
Brandon Morrow (1-0) pitched 3 1-3 innings of one-hit shutout relief for his first major league victory, and J.J. Putz got four outs for his first save of the season.
Kevin Millwood (2-3) allowed five runs and 10 hits in six-plus innings.