A-Rod hit a grand slam off Chris Ray with two outs in the ninth inning, giving the Yankees a memorable 10-7 victory over the Baltimore Orioles on Saturday.
Rodriguez homered twice, doubled and drove in six runs. Igawa left after five mediocre innings, trailing 7-3.
But Jason Giambi hit a three-run homer in the eighth off Danys Baez to get the Yankees close. Ray (0-1) got the first two outs of the ninth before Robinson Cano singled, Derek Jeter walked and Bobby Abreu was hit by a pitch.
Rodriguez then connected on a 1-2 pitch, and knew it was gone as soon as he hit it.
Mariano Rivera (1-0) got the win with a one-hit ninth. Melvin Mora tied a career high with five RBIs for Baltimore.
KANSAS CITY, Mo. - Gary Sheffield, Ivan Rodriguez and Curtis Granderson homered to help Detroit beat Kansas City.
Sheffield, who had just one single in his first three games with the Tigers, homered to left with two outs in the first. Rodriguez homered into the Tigers' bullpen in the fourth to put the Tigers up 4-3. Granderson homered to lead off the fifth.
Mike Maroth (1-0), who was making his first start since May 25 after having arthroscopic elbow surgery last June, picked up the victory, allowing four runs and six hits in five innings.
CHICAGO - Javier Vazquez allowed one hit in 6 2-3 scoreless innings and four relievers completed the frosty three-hitter.
Vazquez (1-0) gave up a leadoff single to Michael Cuddyer in the second inning. It was Minnesota's only hit until Luis Castillo recorded an infield single with two outs in the eighth.
Bobby Jenks pitched the ninth for his first save of the season in as many attempts.
ARLINGTON, Texas - Sammy Sosa hit his first home run since 2005 to help the Rangers get the win.
Sosa hit the first pitch he saw from reliever J.C. Romero in the sixth inning into the left-center field seats for a two-run homer, the 589th of his career.
Kevin Millwood (1-1) went six innings for the Rangers, allowing three runs and eight hits.
Texas got to Boston starter Julian Tavarez (0-1) for four runs and six hits in four innings.
ANAHEIM, Calif. - John Lackey earned his second victory with the help of some shoddy Oakland baserunning, and the Angels beat the Athletics for their fifth win in six games.
Vladimir Guerrero drove in his major league-leading 10th run for the Angels, who are off to their best start since 1991 when they also won five of their first six.
Lackey (2-0) allowed seven hits and one run in seven innings.
ST. PETERSBURG, Fla. - Frank Thomas hit career homer No. 488, a majestic 453-foot grand slam off Devil Rays starter Casey Fossum.
Vernon Wells, Troy Glaus and Reed Johnson also drove in runs for the Blue Jays.
Blue Jays reliever Shaun Marcum (1-0) struck out five of the seven batters he faced in 2 1-3 perfect innings to get the victory.