Nylander planted himself in front of Rick DiPietro during an overtime power play and knocked the puck in with only 48.9 seconds showing. It gave the Rangers their fifth straight victory and moved them past idle Tampa Bay into sixth place in the crowded Eastern Conference playoff chase.
The Islanders, playing their eighth game since Simon was suspended for the rest of the season and playoffs for his two-handed stick swing at Rangers forward Ryan Hollweg on March 8, got a point and jumped into a three-way tie for eighth place with Montreal and Carolina.
The Rangers went on the power play with 1:13 remaining when Islanders defenseman Sean Hill hooked Jaromir Jagr.
DiPietro was sharp in making 32 saves, but the Rangers celebrated their sixth 2-1 victory in 11 games - including three over the Islanders - at center ice. Henrik Lundqvist stopped 34 shots for the Rangers. Colton Orr, Hollweg's hard-hitting linemate, scored his second NHL goal and first in 18 games in the second period. Alexei Yashin tied it for the Islanders with a power-play goal in the third.
PITTSBURGH - Sidney Crosby had two goals and an assist to extend his league scoring lead and help Pittsburgh tie for first place in the Atlantic Division.
Marc-Andre Fleury made 29 saves for his fifth shutout of the season and seventh of his career for Pittsburgh, which is 9-2-1 in its last 12 and tied with the New Jersey Devils atop the Atlantic with 96 points.
Gary Roberts had a goal and two assists, Sergei Gonchar added two assists and Evgeni Malkin and Ryan Malone also scored for the Penguins, who moved to within two points of current No. 4 seed Ottawa.
The Bruins have lost four in a row and seven of nine, and are all but officially eliminated from postseason contention.
CHICAGO - Roman Hamrlik scored off a faceoff with 6:11 left in the third period to snap a tie.
Kristian Huselius and Stephane Yelle also scored for the Flames, who won their third straight. Calgary improved to 90 points and strengthened its hold on eighth place in the Western Conference, the final playoff berth.
Radim Vrbata and Denis Arkhipov scored for Chicago, which lost its fifth straight.
The Blackhawks are in 14th place in the West and have been eliminated from playoff contention for the eighth time in nine seasons.
Khabibulin blocked 27 shots. Calgary's Miikka Kiprusoff made 29 saves.
COLUMBUS, Ohio - Fredrik Modin scored his 20th goal of the season - and 400th point of his career - in Columbus' victory over St. Louis.
Manny Malhotra added a goal and an assist for the Blue Jackets, who got 25 saves from Fredrik Norrena in their third straight win. Derrick Walser and Geoff Platt also scored, and Jason Chimera had three assists.
Doug Weight scored for St. Louis, which has lost three of four.
Columbus is 3-1-3 against the Blues this season and moved within five points of St. Louis for third place in the Western Conference's Central Division. The teams meet again Tuesday night in St. Louis.