Leading 23-12 at the half, the Warriors outscored Cloudland 19-5 in the third quarter to take control of the contest.
Demario Williams led Culleoka (31-6) with 18 points.
Cody Hughes had 11 points for the Highlanders (20-14) who shot just 27 percent (13-of-47).
Other Class A winners included Chattanooga Arts & Sciences over Westside 62-52 while Humboldt beat Wartburg Central 68-59 and Tennessee Temple upended East Literature 47-34.
In Class AA action, Liberty of Jackson blasted Fulton 72-47. White House took on Dyer County in the late game.