The security officials told The Associated Press that 52 civilians and eight police officers died across the country Friday.
The officials spoke on condition of anonymity in line with regulations.
Violence erupted after protesters took to the streets Friday, responding to the Muslim Brotherhood's call following the deaths of 638 people Wednesday when security officials raided two sit-in protests organized by the group. The protests Friday descended into violence when supporters of ousted President Mohammed Morsi clashed with armed vigilantes.
The protesters launched their demonstrations in defiance of a military-imposed state of emergency.