Hood County Sheriff Roger Deeds said he hoped the death toll from the tornado would hold at six, with about 50 people injured and 250 people left homeless.
The twister was part of a swarm of tornadoes unleashed on North Texas, devastating two neighborhoods in southern Granbury and a neighborhood in nearby Cleburne.
"I've been assured by my deputies on the scene that they're pretty confident with the six that they found, but there was a report that two of these people that they found were not even near their homes. So we're going to have to search the area out there," he said.
About 50 people were taken to a Granbury hospital, where 14 were admitted for treatment of injuries and two were transferred to a hospital in Fort Worth, about 35 miles to the northeast, Deeds said.
About 50 people gathered in the Oak Wood Elementary School after nightfall Wednesday to have their injured children examined by paramedics. Five were taken away by ambulance.
As many as 100 people were injured, said Matt Zavadsky, spokesman for MedStar Mobile Healthcare. His company sent three ambulances and a medical bus from its Fort Worth base to Granbury.
Deeds said officials were trying to account for 14 people, but it was not clear if they were missing or were away from the area for other reasons.
Hardest hit were two neighborhoods, Rancho Brazos Estates and DeCordova Ranch, in the southern end of the town of about 8,000 residents about 65 miles southwest of Dallas.
Behind one house in the storm's path sits a detached garage stripped of much of its aluminum siding have with its garage door stove in and its roof torn off. Siding was scattered up to 50 yards away, and bits of fiberglass insulation draped on a fence. A tree behind the house was stripped of most of its branches, and a vacant doublewide mobile home on an adjoining lot was torn apart.
Deeds spoke of a county road operations supervisor who lives in the affected area.
"I've been told his home is destroyed but he was OK, so he was ready to go to work to help his neighbors. But he can't find his truck. The winds were strong enough out there that he still doesn't know where his truck is," Deeds said.
Ambulances from as far away as Fort Worth were being called to Granbury, said Tye Bell, Richland Hills police spokesman who was heading to Granbury on Wednesday night.
The same storm spawned another tornado that storm spotters told the National Weather Service was a mile wide. That twister tore through the southwestern quadrant of Cleburne, a courthouse city of about 30,000 about 25 miles southeast of Granbury.
There were no reports of deaths in that storm, Cleburne Mayor Scott Cain said, "but we do have the potential for some injuries." He had no estimates.
Cain had no estimate on the number of homes damaged, but he said he expected the number to soar into the dozens based on his inspection of damage ranging from roof damage to total destruction.
Another tornado hit the small town of Millsap, about 40 miles west of Fort Worth. Parker County Judge Mark Kelley said roof damage was reported to several houses and a barn was destroyed, but no injuries were reported.
Hail as large as grapefruit also pelted the area around Mineral Wells on Wednesday evening. A police dispatcher reported only minor damage.