The Weather Service says higher elevations could get up to an inch of new snow accumulation during the morning hours, while lower elevations can expect around a half-inch as a result of a cold frontal passage that has moved into the region.
The snow is expected to taper off Wednesday evening and overnight into Thursday.
The Tennessee mountains, and Wise County, Va., are under a winter storm warning until 6 p.m. today.
A winter weather advisory, which encompasses Kingsport, Johnson City and Bristol and Sullivan, Hawkins, Washington counties and parts of Greene County in Tennessee and most of Southwest Virginia, will also remain in effect until midnight Wednesday.
Forecasters expect temperatures throughout the region to remain in the upper 20s and lower 30s, with a 90 percent chance of snow and winds of 15 to 20 mph.
The snow could also lead to possible hazardous driving conditions in higher elevations, according to the forecast.
As of 6:30 a.m., the Tennessee Department of Transportation reported light snow with wet roads and temperatures in the 20s in Washington and Sullivan Counties.
According to the Virginia Department of Transportation, minor icy patches were reported on various routes in Lee and Scott counties, while roads in Wise County ranged from having minor ice patches to moderate snow cover.
The winter weather also effected area schools, with many either closing or going on a 2-hour delay.
In Tennessee, Sullivan County Schools, Hawkins County Schools, Rogersville City Schools, Washington County Schools and Tri-Cities Christian Schools were all closed Wednesday, while Lee County Schools, Scott County Schools and Wise County Schools in Virginia were also closed.
Johnson City Schools were on a two-hour delay, as were Norton City Schools, Bristol, Va. City Schools, Gate City Christian School and Wise County Christian School.