The overall head count of 11,846 students represented an increase of 3.4 percent over last year's 11,455.
"It is gratifying to see the continued growth in our academic program offerings, the quality of our graduates and an increasingly large number of students who select East Tennessee State University as their institution of choice," Stanton said in a news release.
The record was aided by the spring opening of the new ETSU College of Pharmacy with 72 students in its inaugural class. The overall enrollment total for the university also included 476 medical students and residents in the James H. Quillen College of Medicine.
A notable trend at the undergraduate level was the larger number of sophomores and seniors enrolled for spring classes. Sophomore enrollment was up more than 10 percent from last spring, and the number of seniors rose more than 3 percent.
"Student persistence to graduation is a primary focus of our current planning efforts at ETSU," said Bert C. Bach, provost and vice president for academic affairs. "The fact that we are obviously succeeding with these endeavors is a positive reflection on the commendable efforts of our faculty and staff and their concern for student success."
The School of Graduate Studies also reported the highest spring enrollment in the history of the institution, attributable, in part, to an increase of more than 4 percent in the number of students in master's degree programs and a rise of nearly 11 percent in doctoral programs.
ETSU offers doctoral degrees in education, nursing, biomedical sciences, audiology and physical therapy, as well as three new doctoral programs in clinical psychology, environmental health sciences and public health. The university also has professional doctoral degree programs in medicine and pharmacy.
"Graduate student enrollment continues to follow a pattern of growth at ETSU," said, Cecelia McIntosh, Graduate School dean. "ETSU has a reputation for quality graduate education and for offering a wide range of advanced degree programs to provide students with career preparation or career advancement opportunities."