Josh Jackson threw for one touchdown and ran for another for the Hokies (2-0), who showed no ill effects after winning 24-3 at Florida State on Monday night. Jackson went to the bench before halftime with the score 31-7, and backup Ryan Willis led a touchdown drive on his first college series.
The FCS-level Tribe (1-1) were outgained 401-100 in the opening 30 minutes, and 71 of their yards came on a pass from Shon Mitchell to Nick Muse, setting up their lone points in the half.
Peoples scored on runs of 6 and 4 yards and finished with six carries for 55 yards.
Jackson hit 12 of 16 passes for 217 yards, including a 39-yard scoring throw to Damon Hazleton. Jackson also ran 8 yards for a TD, and Deshawn McClease's 1-yard run made it 38-7 at the half.
Mitchell and DeVonte Dedmon hooked up for a 59-yard touchdown in the third quarter.
Before the game, Hall of Fame Hokies coach Frank Beamer met longtime friend and certain future Hall of Famer Jimmye Laycock at midfield for a short recognition. Laycock is retiring following this season, his 39th at the helm of the Tribe, and has a 246-190-2 career record.
William & Mary: The Tribe dominated time of possession last week in a victory at Bucknell but never found any offensive rhythm against the Hokies. William & Mary has played many close games against Power 5 schools in recent years but has lost its last three to the Hokies by a combined score of 140-29.
Virginia Tech: After being a question mark to start the season with eight new starters, the Hokies' young defense was again impressive despite allowing the first touchdown by the Tribe in the past three meetings of the teams. The score came on a 4-yard run by Nate Evans after a 71-yard pass play. Virginia Tech has already allowed plays of 85, 71 and 59 yards this season.
William & Mary drops back down in Colonial Athletic Association play, hosting Elon next Saturday.
Virginia Tech hosts East Carolina, often a nemesis, next Saturday.