Scott announced on Twitter late Monday night that he would undergo chemotherapy every two weeks but would continue to work.
The "SportsCenter" host was first diagnosed with cancer in 2007, when an emergency appendectomy revealed a malignant tumor. He underwent chemotherapy again in 2011.
The 47-year-old Scott joined ESPN in 1993. He quickly became popular for signature phrases such as "Boo-yah!"
He tweeted: "Cancer wants to re-appear..picked the right guy cuz I HIT HARD all day long!!"