The Mets are off to a 5-0 start and are now one game ahead of the Elizabethton Twins.
The Cardinals, meanwhile, are off to a 1-4 start, the second-worst record in the league ahead of winless Burlington.
The Mets racked up 17 hits on the night and were helped out by five Cardinals errors.
Kingsport has accounted for 21 runs in the first two games of the three-game series and 41 runs on the early season, by far the most in the Appy League.
Luis Santana went 4-for-6 for the K-Mets with one RBI, and Ranfy Adon was 3-for-5 with a pair of RBIs.
Dariel Gomez was the lone bright spot for the Cardinals as he hit a two-run homer in the fifth.
The Cardinals left 19 runners on base.
THIRD INNING IS THE CHARM
The K-Mets scored three runs in the top of the third inning, which began courtesy of a throwing error by Cardinals pitcher Javier Villalobos.
Adon reached third base on the play and scored on and Yoel Romero’s single, But the Mets were just getting started.
Shervyen Newton continued his hot start with a double to right and Romero scored. Mark Vientos plated Newton with a single to left.
The Mets were able to pick up right where they left off going into the fourth frame. Raul Beracierta led off the inning with a solo home run to right field.
Adon got his second hit of the night with a triple to dead center. Vientos came up four batters later and hit a three-run shot to right.
The Mets continued to pile it on as they hung seven runs on the Redbirds in the fourth.
CARDS GET ON THE BOARD
In the fifth, Leandro Cedeno got a single, and Gomez hit a two-run blast to right field and got the Cardinals their only two runs of the game.
The Cards totaled 10 hits during the game but left the bases loaded on four separate occasions.
HIT THE SHOWERS
In the top of the sixth, Cardinals manager Roberto Espinoza and K-Mets manager Sean Ratliff were both ejected as there was some controversy over an obstruction call on a throw to second base trying to catch a runner stealing.
The Cards will finish up their series with the K-Mets today with first pitch slated for 5 p.m.